翻訳と辞書 Words near each other ・ Single-valued function ・ Single-vault station ・ Single-vehicle crash ・ Single-walled carbon nanohorn ・ Single-window system ・ Single-wing formation ・ Single-wire earth return ・ Single-board ・ Single-board computer ・ Single-board microcontroller ・ Single-breasted ・ Single-bullet theory ・ Single-camera setup ・ Single-carrier FDMA ・ Single-cell analysis ・ Single-cell DNA template strand sequencing ・ Single-cell protein ・ Single-cell variability ・ Single-celling ・ Single-chain variable fragment ・ Single-chamber ・ Single-chip Cloud Computer ・ Single-cylinder engine ・ Single-dealer platform ・ Single-deck bus ・ Single-domain antibody ・ Single-edged sword ・ Single-elimination tournament ・ Single-ended ・ Single-ended primary-inductor converter Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Single-cell DNA template strand sequencing ： ウィキペディア英語版 Single-cell DNA template strand sequencing Single-cell DNA template strand sequencing, or strand-seq, is a technique for the selective sequencing of a daughter cell’s parental template strands. This technique has many applications, including the identification of sister chromatid exchanges in the parental cell prior to segregation, the identification of misoriented contigs during alignment of reads to the reference genome, and the assessment of non-random segregation of sister chromatids.〔 ==Background== Strand-seq (single strand sequencing) was first described in 2012 as a technique to isolate sequenced reads from parental template strands in single-cell DNA libraries.〔 As a proof of concept study, the authors demonstrated the ability to acquire sequence information from the Watson and/or Crick chromosomal strands in an individual DNA library, depending on the mode of chromatid segregation; a typical DNA library will always contain DNA from both strands. The authors were specifically interested in showing the utility of strand-seq in detecting sister chromatid exchanges (SCEs) at high-resolution. They successfully identified eight putative SCEs in the murine (mouse) embryonic stem (meS) cell line with resolution up to 23 bp. This methodology has also been shown to hold great utility in discerning patterns of non-random chromatid segregation, especially in stem cell lineages. Furthermore, SCEs have been implicated as diagnostic indicators of genome stress, information that has utility in cancer biology. Most research on this topic involves observing the assortment of chromosomal template strands through many cell development cycles and correlating non-random assortment with particular cell fates. Single-cell sequencing protocols were foundational in the development of this technique, but they differ in several aspects. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Single-cell DNA template strand sequencing」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.